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Some call topics (e.g. in Cluster3 & 4) have additional Article 22.5 eligibility requirements. These rules establish ownership and control restrictions designed to protect the strategic interests of the European Union. This infosheet provides a comprehensive overview of what you need to know as an applicant.
Article 22.5 of the Horizon Europe Programme establishes specific eligibility criteria for entities participating in certain EU-funded projects. These restrictions are designed to ensure that projects involving sensitive technologies, such as AI and robotics, remain under appropriate control and don't pose risks to EU strategic interests.
Legal Entities from the following countries are generally eligible to participate:
The key requirement under Article 22.5 is that entities must not be controlled by non-eligible countries or their entities. Here's what you need to know:
Control is assessed based on several factors:
The ownership and control assessment occurs at the following moments:
At the proposal stage, beneficiaries must fill in the Ownership and Control Assessment template, providing detailed information about:
The European Commission's Central Validation Services (CVS) receives and reviews your OCA template. They may request additional information or clarification as needed.
The operational unit responsible for your call reviews the CVS conclusions and makes a determination about eligibility.
For Horizon Europe projects, the Commission also consults with contact points in eligible member states and associated countries to obtain their assessment.
If your entity is found to be controlled by a non-eligible country or entity, it doesn't automatically mean you're excluded. You have the option to participate exceptionally if you can provide sufficient guarantees that your participation does not pose risks to EU strategic interests.
To demonstrate sufficient guarantees, you'll need to complete additional templates showing:
The Commission will assess whether these guarantees adequately protect EU strategic interests on a case-by-case basis.
It's crucial to understand that ownership and control can change after a proposal is submitted or even after a grant agreement is signed. If this happens:
The European Commission understands that ownership and control information can be commercially sensitive. All information provided in the OCA process remains confidential within the Commission and is not shared externally.
If you're applying for a project that will provide Financial Support to Third Parties (FSTP), there are additional considerations regarding Article 22.5 compliance:
As an FSTP manager (the consortium managing the FSTP cascade funding), you are responsible for implementing EC rules and ensuring that FSTP recipients meet eligibility requirements, including Article 22.5 restrictions where applicable.
Recognizing the administrative burden of applying full Article 22.5 checks to potentially hundreds of FSTP recipients, the Commission has introduced simplified rules for the 2026 work programme:
Even with simplified rules, FSTP managers should establish processes to monitor significant ownership changes among FSTP recipients during the project period, as these could affect eligibility and compliance with grant conditions.
The Commission has developed specific guidance documents for FSTP implementation, including how to apply Article 22.5 requirements. Make sure that you contact your Project Officer so that you get the relevant documents. Of course, also check any call-specific guidance documents carefully, and then establish clear eligibility criteria in your FSTP open calls and develop appropriate templates and processes for FSTP recipient assessment.
For questions specific to FSTP implementation and Article 22.5 requirements, FSTP managers are encouraged to contact the relevant Commission operational unit for clarification. Ask help to your NCPs if you don't know how to reach them.
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The Department of Economy, Science and Innovation of the Flemish government coordinates the Horizon 2020 Coordination and Support Action SAPHIRe, which started on 1 December 2018. The aim of the project is to secure the adoption of personalised medicine in all European regions, including sparsely populated and remote regions and regions with different innovation capacities.
The activities of SAPHIRe are complementary to the smart specialisation partnership on personalised medicine – S3P4PM, which is also coordinated by the Department of Economy, Science and Innovation.